<?xml version="1.0" encoding="UTF-8"?>
<rss version="2.0"
	xmlns:content="http://purl.org/rss/1.0/modules/content/"
	xmlns:wfw="http://wellformedweb.org/CommentAPI/"
	xmlns:dc="http://purl.org/dc/elements/1.1/"
	xmlns:atom="http://www.w3.org/2005/Atom"
	xmlns:sy="http://purl.org/rss/1.0/modules/syndication/"
	xmlns:slash="http://purl.org/rss/1.0/modules/slash/"
	
	xmlns:media="http://search.yahoo.com/mrss/"
	>

<channel>
	<title>Fuzzier Logic</title>
	<atom:link href="http://blog.fuzzierlogic.com/feed" rel="self" type="application/rss+xml" />
	<link>http://blog.fuzzierlogic.com</link>
	<description>Logic. Just a bit woolier.</description>
	<lastBuildDate>Tue, 22 Nov 2011 09:21:38 +0000</lastBuildDate>
	<language>en</language>
	<sy:updatePeriod>hourly</sy:updatePeriod>
	<sy:updateFrequency>1</sy:updateFrequency>
	<generator>http://wordpress.org/?v=3.3.1</generator>
		<item>
		<title>Making an RSS feed from Google Reader shared items</title>
		<link>http://blog.fuzzierlogic.com/archives/18184</link>
		<comments>http://blog.fuzzierlogic.com/archives/18184#comments</comments>
		<pubDate>Mon, 21 Nov 2011 22:35:33 +0000</pubDate>
		<dc:creator>Simon</dc:creator>
				<category><![CDATA[internet]]></category>
		<category><![CDATA[Technical]]></category>
		<category><![CDATA[google-reader]]></category>
		<category><![CDATA[rss]]></category>

		<guid isPermaLink="false">http://blog.fuzzierlogic.com/?p=18184</guid>
		<description><![CDATA[<p>A month ago there would have been no reason to write this post, because Google Reader made it&#8217;s own RSS feed of the posts you wanted to share. See, Google wants to drive people to use Google+, and they seem to be doing this by crippling their other services that have even a smidgen of [...]]]></description>
			<content:encoded><![CDATA[<div class="kcite-section" kcite-section-id="18184">
<!-- coins metadata inserted by kblog-metadata -->
<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&amp;rfr_id=kblog-metadata.php&amp;rft.title=Making+an+RSS+feed+from+Google+Reader+shared+items&amp;rft.source=Fuzzier+Logic&amp;rft.date=2011-11-21&amp;rft.identifier=http%3A%2F%2Fblog.fuzzierlogic.com%2Farchives%2F18184&amp;rft.aulast=Cockell&amp;rft.aufirst=Simon&amp;rft.format=text&amp;rft.language=English"></span><p>A month ago there would have been no reason to write this post, because Google Reader made it&#8217;s own RSS feed of the posts you wanted to share. See, Google wants to drive people to use Google+, and they seem to be doing this by crippling their other services that have even a smidgen of social usefulness. The thing is, I liked the social bits of Google Reader. Sure, they were a bit of an afterthought, and mildly dysfunctional, but I got a lot of value from reading what other people shared, and I liked that when I shared something I was creating a kind of archive of stuff I liked on Reader, with an RSS feed of its very own.</p>
<p>The great thing about RSS is that it can be consumed by arbitrary 3rd party applications. The likes of Google, Facebook and Twitter don&#8217;t like this, because they want control over the 3rd parties that can access their stream. So they are quite prepared to kill off RSS services in their applications, because it does not serve their mission. You can no longer get an RSS feed of your Twitter stream (as far as I know), there is no RSS built into Google+ (which I have yet to have the time to fully grok).</p>
<p>My needs are small, I want an RSS feed of the stuff I want to share from Google Reader, so that other people can follow the things I share in Reader (if they want), and I can pipe that information elsewhere (I use <a href="http://dlvr.it/" title="dlvr.it">dlvr.it</a> to post selected RSS feeds into Twitter). Google doesn&#8217;t want to provide that anymore, so I&#8217;ll hack something together.</p>
<p>The ingredients:</p>
<ol>
<li><a href="http://www.webreference.com/authoring/languages/xml/rss/custom_feeds/index.html" title="Make an RSS feed from a MySQL database">These simple instructions</a> for how to render an RSS feed from a MySQL backend.</li>
<li>The instructions for <a href="http://www.mattcutts.com/blog/google-reader-adds-send-to-feature/" title="Google Reader Send To">how to create your own &#8220;Send to:&#8221;</a> item in Google Reader</li>
<li>My rudimentary PHP hackery skills</li>
</ol>
<p>The code:<br />
All source is available on <a href="https://bitbucket.org/sjcockell/readershare/" title="ReaderShare on BitBucket">BitBucket</a>.</p>
<p>First, we need a database connection. The database is set up exactly as described in (1), above.</p>
<pre class="brush: php; title: ; notranslate">
&lt;?php
DEFINE('DB_USER', 'db_user');
DEFINE('DB_PASSWORD', 'db_password');
DEFINE('DB_HOST', 'localhost');
DEFINE('DB_NAME', 'db_name');
// Make the connnection and then select the database.
$dbc = @mysql_connect(DB_HOST, DB_USER, DB_PASSWORD) OR die(mysql_error());
mysql_select_db(DB_NAME) OR die(mysql_error());
?&gt;
</pre>
<p>Now, when the page is visited, we want to render what is in the database as an RSS feed (again, this is a simple adaptation of the code in (1)):</p>
<pre class="brush: php; title: ; notranslate">
&lt;?php
  class RSS {
        public function RSS() {
                require_once ('mysql_connect.php');
        }
        public function GetFeed() {
                return $this-&gt;getDetails() . $this-&gt;getItems();
        }
        private function dbConnect() {
                DEFINE('LINK', mysql_connect(DB_HOST, DB_USER, DB_PASSWORD));
        }
        private function getDetails() {
                //header of the RSS feed
                $detailsTable = &quot;webref_rss_details&quot;;
                $this-&gt;dbConnect($detailsTable);
                $query = &quot;SELECT * FROM &quot;. $detailsTable;
                $result = mysql_db_query (DB_NAME, $query, LINK);
                while($row = mysql_fetch_array($result)) {
                        //fairly minimal description of the feed
                        $details = '&lt;?xml version=&quot;1.0&quot; encoding=&quot;ISO-8859-1&quot; ?&gt;
                                &lt;rss version=&quot;2.0&quot;&gt;
                                        &lt;channel&gt;
                                                &lt;title&gt;'. $row['title'] .'&lt;/title&gt;
                                                &lt;link&gt;'. $row['link'] .'&lt;/link&gt;
                                                &lt;description&gt;'. $row['description'] .'&lt;/description&gt;
                                                &lt;language&gt;'. $row['language'] .'&lt;/language&gt;
                                                ';
                }
                return $details;
        }

        private function getItems() {
                //return all the items foe the RSS feed
                $itemsTable = &quot;webref_rss_items&quot;;
                $this-&gt;dbConnect($itemsTable);
                $query = &quot;SELECT * FROM &quot;. $itemsTable;
                $result = mysql_db_query(DB_NAME, $query, LINK);
                $items = '';
                while($row = mysql_fetch_array($result)) {
                        $items .= '&lt;item&gt;
                                &lt;title&gt;'. $row[&quot;title&quot;] .'&lt;/title&gt;
                                &lt;link&gt;'. $row[&quot;link&quot;] .'&lt;/link&gt;
                                &lt;description&gt;&lt;![CDATA['. $row[&quot;description&quot;] .']]&gt;&lt;/description&gt;
                        &lt;/item&gt;';
                }
                //close the feed
                $items .= '&lt;/channel&gt;
                                &lt;/rss&gt;';
                return $items;
        }
}
?&gt;
</pre>
<p>Finally, we need a method for adding new stuff for the feed. This code takes the GET variables passed to it by Google Reader, and stores them in the DB:</p>
<pre class="brush: php; title: ; notranslate">
&lt;?php
if ($_GET['url']) {
        //receive google reader 'send to' items, and store in mysqldb
        $url = $_GET['url'];
        $source = $_GET['source'];
        $title = $_GET['title'];
        $simple_check = $_GET['check'];
        //stops anyone adding new items to your feed unless they have the key
        if ($simple_check == 'uniquepasscodehere') {
                //statement adds new item to RSS database
                $insert_statement = &quot;INSERT INTO webref_rss_items(title, description, link) VALUES('$title', '$source', '$url')&quot;;
                require_once('mysql_connect.php');
                $result = mysql_query($insert_statement, $dbc);
                if ($result) {
                        echo &quot;&lt;p&gt;Success!&quot;;
                        //would be nice to close the window automatically after a couple of seconds
                }
                else {
                        die('&lt;p&gt;Invalid query: ' . mysql_error());
                }
        }
}
else {
        //render everything in the db as RSS
        header(&quot;Content-Type: application/xml; charset=ISO-8859-1&quot;);
        include(&quot;RSS.class.php&quot;);
        $rss = new RSS();
        echo $rss-&gt;GetFeed();
}
?&gt;
</pre>
<p>Now, I can set up the Send To: item in Google Reader:</p>
<p><a href="http://blog.fuzzierlogic.com/wp-content/uploads/2011/11/Screen-Shot-2011-11-21-at-22.22.49.png"><img src="http://blog.fuzzierlogic.com/wp-content/uploads/2011/11/Screen-Shot-2011-11-21-at-22.22.49.png" alt="" title="Add GReader &quot;Send To&quot;" width="527" height="169" class="aligncenter size-full wp-image-18189" /></a></p>
<p>Finally, click &#8216;Send To: -> Readershare&#8217; in the footer of an item in Google Reader, and it is rendered into my RSS feed, which can then be consumed by other applications, including Google Reader itself (so if you want to subscribe to my Google Reader shared items feed, you can find it at <a href="http://fuzzierlogic.com/readershare" title="ReaderShare">http://fuzzierlogic.com/readershare</a>). Oh, and I can pipe my Google Reader shares back into Twitter again.</p>
<!-- kcite active, but no citations found -->
</div> <!-- kcite-section 18184 -->]]></content:encoded>
			<wfw:commentRss>http://blog.fuzzierlogic.com/archives/18184/feed</wfw:commentRss>
		<slash:comments>0</slash:comments>
	
		<media:thumbnail url="http://blog.fuzzierlogic.com/wp-content/uploads/2011/11/Screen-Shot-2011-11-21-at-22.22.49-150x150.png" />
		<media:content url="http://blog.fuzzierlogic.com/wp-content/uploads/2011/11/Screen-Shot-2011-11-21-at-22.22.49.png" medium="image">
			<media:title type="html">Add GReader &#8220;Send To&#8221;</media:title>
			<media:thumbnail url="http://blog.fuzzierlogic.com/wp-content/uploads/2011/11/Screen-Shot-2011-11-21-at-22.22.49-150x150.png" />
		</media:content>
	</item>
		<item>
		<title>R programming courses at Newcastle University</title>
		<link>http://blog.fuzzierlogic.com/archives/17330</link>
		<comments>http://blog.fuzzierlogic.com/archives/17330#comments</comments>
		<pubDate>Thu, 22 Sep 2011 15:49:01 +0000</pubDate>
		<dc:creator>Simon</dc:creator>
				<category><![CDATA[Uncategorized]]></category>

		<guid isPermaLink="false">http://blog.fuzzierlogic.com/?p=17330</guid>
		<description><![CDATA[<p>An announcement courtesy of <a href="http://csgillespie.wordpress.com/" target="_blank">Colin Gillespie</a>, a lecturer in <a href="http://www.ncl.ac.uk/maths/" title="Newcastle University School of Maths and Stats" target="_blank">Maths &#038; Stats</a> here in Newcastle:</p> <p><a href="http://www.ncl.ac.uk/maths/" target="_blank">The School of Mathematics &#038; Statistics</a> at <a href="http://www.ncl.ac.uk/" target="_blank">Newcastle University</a>, are<br /> again running some R courses. In January, 2012, we will run:</p> January 16th: Introduction [...]]]></description>
			<content:encoded><![CDATA[<div class="kcite-section" kcite-section-id="17330">
<!-- coins metadata inserted by kblog-metadata -->
<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&amp;rfr_id=kblog-metadata.php&amp;rft.title=R+programming+courses+at+Newcastle+University&amp;rft.source=Fuzzier+Logic&amp;rft.date=2011-09-22&amp;rft.identifier=http%3A%2F%2Fblog.fuzzierlogic.com%2Farchives%2F17330&amp;rft.aulast=Cockell&amp;rft.aufirst=Simon&amp;rft.format=text&amp;rft.language=English"></span><p>An announcement courtesy of <a href="http://csgillespie.wordpress.com/" target="_blank">Colin Gillespie</a>, a lecturer in <a href="http://www.ncl.ac.uk/maths/" title="Newcastle University School of Maths and Stats" target="_blank">Maths &#038; Stats</a> here in Newcastle:</p>
<p><a href="http://www.ncl.ac.uk/maths/" target="_blank">The School of Mathematics &#038; Statistics</a> at <a href="http://www.ncl.ac.uk/" target="_blank">Newcastle University</a>, are<br />
again running some R courses. In January, 2012, we will run:</p>
<ul>
<li>January 16th: Introduction to R;
</li>
<li>January 17th: Programming with R;
</li>
<li>January 18th &#038; 19th: Advanced graphics with R.
</li>
</ul>
<p>The courses aren’t aimed at teaching statistics, rather they aim to go through the fundemental concepts of R programming. </p>
<p>Further information is available at the <a href="http://www.ncl.ac.uk/maths/rcourse/" target="_blank">course website</a>.</p>
<!-- kcite active, but no citations found -->
</div> <!-- kcite-section 17330 -->]]></content:encoded>
			<wfw:commentRss>http://blog.fuzzierlogic.com/archives/17330/feed</wfw:commentRss>
		<slash:comments>0</slash:comments>
	
	</item>
		<item>
		<title>Science Online London 2011</title>
		<link>http://blog.fuzzierlogic.com/archives/16841</link>
		<comments>http://blog.fuzzierlogic.com/archives/16841#comments</comments>
		<pubDate>Thu, 08 Sep 2011 11:39:19 +0000</pubDate>
		<dc:creator>Simon</dc:creator>
				<category><![CDATA[Science Online 2011]]></category>
		<category><![CDATA[Conference]]></category>
		<category><![CDATA[solo11]]></category>

		<guid isPermaLink="false">http://blog.fuzzierlogic.com/?p=16841</guid>
		<description><![CDATA[<p>It is hard not to get carried away in a room full of people who seem mostly to want the same things. You come away from a conference like <a href="http://www.scienceonlinelondon.org/" title="Science Online London 2011" target="_blank">Science Online</a> thinking that the open science revolution is inevitable, and there is nothing anyone can do to stop it. [...]]]></description>
			<content:encoded><![CDATA[<div class="kcite-section" kcite-section-id="16841">
<!-- coins metadata inserted by kblog-metadata -->
<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&amp;rfr_id=kblog-metadata.php&amp;rft.title=Science+Online+London+2011&amp;rft.source=Fuzzier+Logic&amp;rft.date=2011-09-08&amp;rft.identifier=http%3A%2F%2Fblog.fuzzierlogic.com%2Farchives%2F16841&amp;rft.aulast=Cockell&amp;rft.aufirst=Simon&amp;rft.format=text&amp;rft.language=English"></span><p>It is hard not to get carried away in a room full of people who seem mostly to want the same things. You come away from a conference like <a href="http://www.scienceonlinelondon.org/" title="Science Online London 2011" target="_blank">Science Online</a> thinking that the open science revolution is inevitable, and there is nothing anyone can do to stop it. Then you get back to your day job and talk of <a href="http://www.hefce.ac.uk/research/ref/" title="Research Excellence Framework" target="_blank">REF</a> and <a href="http://en.wikipedia.org/wiki/Impact_factor" title="Journal Impact Factor" target="_blank">impact factors</a> and get bought back to earth with a bump.</p>
<div class="mceTemp">
<dl class="wp-caption alignright" style="width: 310px;">
<dt class="wp-caption-dt"><a href="http://blog.fuzzierlogic.com/wp-content/uploads/2011/09/solo11.png"><img class="size-medium wp-image-16842" title="solo11 Word Cloud" src="http://blog.fuzzierlogic.com/wp-content/uploads/2011/09/solo11-300x231.png" alt="#solo11 tweets" width="300" height="231" /></a><br />
<h1 class="wp-caption-dd">Word Cloud of #solo11 Tweets (tagxedo.com)</h1>
</dt>
</dl>
</div>
<p>The take home message of the conference this year seemed to be this: for open science to work, long term, reward mechanisms within the profession have to change in a comprehensive and profound way. Do I think this is possible? Of course. Do I think this is inevitable? Not by a long chalk. There are too many parties with a vested interest in things remaining the same, some of whom were represented here, despite all of the talk being about openness.</p>
<p><a href="http://www.nature.com/" title="Nature Publishing Group" target="_blank">NPG</a> certainly don&#8217;t seem that interested in opening things up too far, as the breakout session on APIs demonstrated. Nothing outside of their paywall was discussed, even more broadly applicable tools, like <a href="http://www.connotea.org/" title="Connotea" target="_blank">Connotea</a>, seem to be quietly dropped in the background. The research councils are still more interested in &#8220;impact&#8221; (whatever that means) than genuinely original thinking.</p>
<p>But for all this pessimism, there are interesting things happening, and a mainstream breakthrough becomes more likely as the volume of those agitating for change grows. <a href="http://ncmir.ucsd.edu/contact/personnel/maryann_martone.shtm" target="_blank">MaryAnn Martone</a>&#8216;s keynote was genuinely inspiring, a clear case for breaking down the garden walls. <a href="http://michaelnielsen.org/blog/michael-a-nielsen/" target="_blank">Michael Nielsen</a> made a compelling case for wholesale revolution (however unlikely I think this sort of change may be). We showed that in an afternoon, you can set up a <a href="http://blogs.scienceonlinelondon.org/" title="Science Online Blogging Workshop" target="_blank">collaborative blog</a> and populate it with interesting scientific content, using freely available tools. The interest we always encounter for the <a href="http://knowledgeblog.org" title="Knowledgeblog" target="_blank">Knowledgeblog</a> project enthuses me, and encourages me that something similar will make hay someday soon (even if we don&#8217;t manage to be the people who make the breakthrough).</p>
<p>It may be difficult for me to get to SoLo12, but I will try very hard to return, because I always leave with a smile on my face.</p>
<!-- kcite active, but no citations found -->
</div> <!-- kcite-section 16841 -->]]></content:encoded>
			<wfw:commentRss>http://blog.fuzzierlogic.com/archives/16841/feed</wfw:commentRss>
		<slash:comments>0</slash:comments>
	
		<media:thumbnail url="http://blog.fuzzierlogic.com/wp-content/uploads/2011/09/solo11.png" />
		<media:content url="http://blog.fuzzierlogic.com/wp-content/uploads/2011/09/solo11.png" medium="image">
			<media:title type="html">solo11 Word Cloud</media:title>
			<media:description type="html">Wird Cloud of #solo11 Tweets (tagxedo.com)</media:description>
		</media:content>
	</item>
		<item>
		<title>Salbutamol promotes SMN2 expression</title>
		<link>http://blog.fuzzierlogic.com/archives/16515</link>
		<comments>http://blog.fuzzierlogic.com/archives/16515#comments</comments>
		<pubDate>Mon, 05 Sep 2011 11:02:26 +0000</pubDate>
		<dc:creator>Simon</dc:creator>
				<category><![CDATA[Research Blogging]]></category>
		<category><![CDATA[Science Online 2011]]></category>
		<category><![CDATA[spinal-muscular-atrophy]]></category>

		<guid isPermaLink="false">http://blog.fuzzierlogic.com/?p=16515</guid>
		<description><![CDATA[<p>This is a <a href='http://blogs.scienceonlinelondon.org/blog/2011/09/03/salbutamol-promotes-smn2-expression/'>cross-post</a> from the <a href='http://blogs.scienceonlinelondon.org/'>Blogging for Science Online London</a> group blog. During the Saturday workshop at <a href='http://www.scienceonlinelondon.org/'>Science Online London 2011</a>, a bunch of us wrote content relating to Spinal Muscular Atrophy. My post was a short summary of a small scale drug trial, which shows promising results.</p> <p>This is a [...]]]></description>
			<content:encoded><![CDATA[<div class="kcite-section" kcite-section-id="16515">
<!-- coins metadata inserted by kblog-metadata -->
<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&amp;rfr_id=kblog-metadata.php&amp;rft.title=Salbutamol+promotes+SMN2+expression&amp;rft.source=Fuzzier+Logic&amp;rft.date=2011-09-05&amp;rft.identifier=http%3A%2F%2Fblog.fuzzierlogic.com%2Farchives%2F16515&amp;rft.aulast=Cockell&amp;rft.aufirst=Simon&amp;rft.format=text&amp;rft.language=English"></span><p>This is a <a href='http://blogs.scienceonlinelondon.org/blog/2011/09/03/salbutamol-promotes-smn2-expression/'>cross-post</a> from the <a href='http://blogs.scienceonlinelondon.org/'>Blogging for Science Online London</a> group blog. During the Saturday workshop at <a href='http://www.scienceonlinelondon.org/'>Science Online London 2011</a>, a bunch of us wrote content relating to Spinal Muscular Atrophy. My post was a short summary of a small scale drug trial, which shows promising results.</p>
<p>This is a summary of a paper that shows that Salbutamol promotes SMN2 expression <em>in vivo</em> <span class="kcite" kcite-id="ITEM-1">(<a href="http://dx.doi.org/10.1136/jmg.2010.080366">http://dx.doi.org/10.1136/jmg.2010.080366</a>)</span>
. </p>
<p>Patients with Spinal Muscular Atrophy (SMA) have no functioning copy of the gene <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&amp;cmd=Retrieve&amp;dopt=full_report&amp;list_uids=6606&amp;itool=HomoloGeneMainReport">SMN1</a>. The <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&amp;cmd=Retrieve&amp;dopt=full_report&amp;list_uids=6607&amp;itool=HomoloGeneMainReport">SMN2</a> gene can theoretically function in its place, but a change in this gene means that only a small amount of functional protein is produced from the gene. </p>
<p>It is therefore suggested that any intervention that can increase the level of functional SMN2 transcript could well be effective as a treatment for SMA. </p>
<p><a href="http://www.ebi.ac.uk/chebi/searchId.do;D2D6E4DB8A56AC5C6C0F34326B11E5A0?chebiId=CHEBI:8746">Salbutamol</a> is a short acting beta-adrenergic agonist that is primarily used for treating asthma. A previous study <span class="kcite" kcite-id="ITEM-2">(<a href="http://dx.doi.org/10.1136/jmg.2007.051177">http://dx.doi.org/10.1136/jmg.2007.051177</a>)</span>
 has shown that Salbutamol is effective in raising SMN2 full length (SMN2-fl) levels in cultured SMA fibroblasts. </p>
<p><a href="http://jmg.bmj.com/content/47/12/856/F1.large.jpg"><img class="alignleft" src="http://jmg.bmj.com/content/47/12/856/F1.large.jpg" alt="Figure 1" width="250" /></a> </p>
<p>In this study, the researchers administered Salbutamol to 12 patients with SMA, and measured the levels of SMN2-fl 3 times (0, 3 and 6 months). The levels of SMN2-fl were significantly increased in all but 3 patients after 3 months (average increase of 48.9%), and in all patients after 6 months (average increase of 91.8%). They also showed that patients with more copies of the SMN2 gene (some patients had 3 copies, some had 4) showed a larger response to Salbutamol treatment. This increase in expression cannot be explained by normal fluctuations over time in these patients, since studies have shown that levels of SMN2-fl are usually stable over time <span class="kcite" kcite-id="ITEM-3">(<a href="http://dx.doi.org/10.1212/01.wnl.0000252934.70676.ab">http://dx.doi.org/10.1212/01.wnl.0000252934.70676.ab</a>)</span>
 <span class="kcite" kcite-id="ITEM-4">(<a href="http://dx.doi.org/10.1038/ejhg.2009.116">http://dx.doi.org/10.1038/ejhg.2009.116</a>)</span>
. Clearly the big question now is whether this molecular response to the drug is reflected in a beneficial clinical response in the patient. This study does not address this question, but does propose that a full double-blind, placebo controlled trial should be carried out to ascertain whether or not this treatment is effective in treating the symptoms of SMA.</p>
<p><span style="float: left; padding: 5px;"><a href="http://www.researchblogging.org"><img alt="ResearchBlogging.org" src="http://www.researchblogging.org/public/citation_icons/rb2_large_gray.png" style="border:0;"/></a></span><span class="Z3988" title="ctx_ver=Z39.88-2004&#038;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&#038;rft.jtitle=Journal+of+Medical+Genetics&#038;rft_id=info%3Adoi%2F10.1136%2Fjmg.2010.080366&#038;rfr_id=info%3Asid%2Fresearchblogging.org&#038;rft.atitle=Salbutamol+increases+survival+motor+neuron+%28SMN%29+transcript+levels+in+leucocytes+of+spinal+muscular+atrophy+%28SMA%29+patients%3A+relevance+for+clinical+trial+design&#038;rft.issn=0022-2593&#038;rft.date=2010&#038;rft.volume=47&#038;rft.issue=12&#038;rft.spage=856&#038;rft.epage=858&#038;rft.artnum=http%3A%2F%2Fjmg.bmj.com%2Fcgi%2Fdoi%2F10.1136%2Fjmg.2010.080366&#038;rft.au=Tiziano%2C+F.&#038;rft.au=Lomastro%2C+R.&#038;rft.au=Pinto%2C+A.&#038;rft.au=Messina%2C+S.&#038;rft.au=D%27Amico%2C+A.&#038;rft.au=Fiori%2C+S.&#038;rft.au=Angelozzi%2C+C.&#038;rft.au=Pane%2C+M.&#038;rft.au=Mercuri%2C+E.&#038;rft.au=Bertini%2C+E.&#038;rft.au=Neri%2C+G.&#038;rft.au=Brahe%2C+C.&#038;rfe_dat=bpr3.included=1;bpr3.tags=Biology%2CMedicine%2CPharmacology">Tiziano, F., Lomastro, R., Pinto, A., Messina, S., D&#8217;Amico, A., Fiori, S., Angelozzi, C., Pane, M., Mercuri, E., Bertini, E., Neri, G., &#038; Brahe, C. (2010). Salbutamol increases survival motor neuron (SMN) transcript levels in leucocytes of spinal muscular atrophy (SMA) patients: relevance for clinical trial design <span style="font-style: italic;">Journal of Medical Genetics, 47</span> (12), 856-858 DOI: <a rev="review" href="http://dx.doi.org/10.1136/jmg.2010.080366">10.1136/jmg.2010.080366</a></span></p>


<p>Bibliography
      <div class="kcite-bibliography"></div>
</p>


<script type="text/javascript">
      var kcite_citation_data;
      if( kcite_citation_data == undefined ){
          kcite_citation_data = [];
      }
      kcite_citation_data[ 16515 ] = {"ITEM-1":{"volume":"47","issue":"12","URL":"http://dx.doi.org/10.1136/jmg.2010.080366","title":"Salbutamol increases survival motor neuron (SMN) transcript levels in leucocytes of spinal muscular atrophy (SMA) patients: relevance for clinical trial design","container-title":"Journal of Medical Genetics","publisher":"BMJ Publishing Group","issued":{"date-parts":[[2010,11,22]]},"author":[{"family":"Tiziano","given":"F. D."},{"family":"Lomastro","given":"R."},{"family":"Pinto","given":"A. M."},{"family":"Messina","given":"S."},{"family":"D'Amico","given":"A."},{"family":"Fiori","given":"S."},{"family":"Angelozzi","given":"C."},{"family":"Pane","given":"M."},{"family":"Mercuri","given":"E."},{"family":"Bertini","given":"E."},{"family":"Neri","given":"G."},{"family":"Brahe","given":"C."}],"editor":[],"page":"856-858","type":"article-journal","source":"doi","identifier":"10.1136/jmg.2010.080366","resolved":true,"id":"ITEM-1"},"ITEM-2":{"volume":"45","issue":"1","URL":"http://dx.doi.org/10.1136/jmg.2007.051177","title":"Salbutamol increases SMN mRNA and protein levels in spinal muscular atrophy cells","container-title":"Journal of Medical Genetics","publisher":"BMJ Publishing Group","issued":{"date-parts":[[2007,10,26]]},"author":[{"family":"Angelozzi","given":"C"},{"family":"Borgo","given":"F"},{"family":"Tiziano","given":"F D"},{"family":"Martella","given":"A"},{"family":"Neri","given":"G"},{"family":"Brahe","given":"C"}],"editor":[],"page":"29-31","type":"article-journal","source":"doi","identifier":"10.1136/jmg.2007.051177","resolved":true,"id":"ITEM-2"},"ITEM-3":{"volume":"68","issue":"6","URL":"http://dx.doi.org/10.1212/01.wnl.0000252934.70676.ab","title":"Preclinical validation of a multiplex real-time assay to quantify SMN mRNA in patients with SMA","container-title":"Neurology","publisher":"Ovid Technologies (Wolters Kluwer Health)","issued":{"date-parts":[[2007,2,5]]},"author":[{"family":"Simard","given":"L. R."},{"family":"Belanger","given":"M-C"},{"family":"Morissette","given":"S."},{"family":"Wride","given":"M."},{"family":"Prior","given":"T. W."},{"family":"Swoboda","given":"K. J."}],"editor":[],"page":"451-456","type":"article-journal","source":"doi","identifier":"10.1212/01.wnl.0000252934.70676.ab","resolved":true,"id":"ITEM-3"},"ITEM-4":{"volume":"18","issue":"1","URL":"http://dx.doi.org/10.1038/ejhg.2009.116","title":"SMN transcript levels in leukocytes of SMA patients determined by absolute real-time PCR","container-title":"European Journal of Human Genetics","publisher":"Nature Publishing Group","issued":{"date-parts":[[2009,7,15]]},"author":[{"family":"Tiziano","given":"Francesco Danilo"},{"family":"Pinto","given":"Anna Maria"},{"family":"Fiori","given":"Stefania"},{"family":"Lomastro","given":"Rosa"},{"family":"Messina","given":"Sonia"},{"family":"Bruno","given":"Claudio"},{"family":"Pini","given":"Antonella"},{"family":"Pane","given":"Marika"},{"family":"D'Amico","given":"Adele"},{"family":"Ghezzo","given":"Alessandro"},{"family":"Bertini","given":"Enrico"},{"family":"Mercuri","given":"Eugenio"},{"family":"Neri","given":"Giovanni"},{"family":"Brahe","given":"Christina"}],"editor":[],"page":"52-58","type":"article-journal","source":"doi","identifier":"10.1038/ejhg.2009.116","resolved":true,"id":"ITEM-4"}};
</script>


</div> <!-- kcite-section 16515 -->]]></content:encoded>
			<wfw:commentRss>http://blog.fuzzierlogic.com/archives/16515/feed</wfw:commentRss>
		<slash:comments>0</slash:comments>
	
		<media:thumbnail url="http://jmg.bmj.com/content/47/12/856/F1.large.jpg" />
		<media:content url="http://jmg.bmj.com/content/47/12/856/F1.large.jpg" medium="image">
			<media:title type="html">Figure 1</media:title>
		</media:content>
		<media:content url="http://www.researchblogging.org/public/citation_icons/rb2_large_gray.png" medium="image">
			<media:title type="html">ResearchBlogging.org</media:title>
		</media:content>
	</item>
		<item>
		<title>Position available in the Bioinformatics Support Unit, Newcastle</title>
		<link>http://blog.fuzzierlogic.com/archives/14925</link>
		<comments>http://blog.fuzzierlogic.com/archives/14925#comments</comments>
		<pubDate>Thu, 11 Aug 2011 15:29:44 +0000</pubDate>
		<dc:creator>Simon</dc:creator>
				<category><![CDATA[Jobs]]></category>
		<category><![CDATA[bsu]]></category>
		<category><![CDATA[jobs]]></category>

		<guid isPermaLink="false">http://blog.fuzzierlogic.com/?p=14925</guid>
		<description><![CDATA[<p>Further to my <a title="Fuzzierlogic - Brand new same old job" href="http://blog.fuzzierlogic.com/archives/12593">last post</a>, I am able to announce the availability of a position in the BSU, to work with me (it&#8217;s my old job!)</p> <p>Official details are below, or you can find the full ad on the <a title="Job Advert" href="http://www15.i-grasp.com/fe/tpl_newcastle02.asp?s=zDmOlRWtGeVHmJjVeb&#38;jobid=41653,4722349883&#38;key=27835358&#38;c=478665875699&#38;pagestamp=dbxbhpfwxemtrgkrba">Newcastle University website</a>.</p> <p>Experimental Scientific [...]]]></description>
			<content:encoded><![CDATA[<div class="kcite-section" kcite-section-id="14925">
<!-- coins metadata inserted by kblog-metadata -->
<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&amp;rfr_id=kblog-metadata.php&amp;rft.title=Position+available+in+the+Bioinformatics+Support+Unit%2C+Newcastle&amp;rft.source=Fuzzier+Logic&amp;rft.date=2011-08-11&amp;rft.identifier=http%3A%2F%2Fblog.fuzzierlogic.com%2Farchives%2F14925&amp;rft.aulast=Cockell&amp;rft.aufirst=Simon&amp;rft.format=text&amp;rft.language=English"></span><p>Further to my <a title="Fuzzierlogic - Brand new same old job" href="http://blog.fuzzierlogic.com/archives/12593">last post</a>, I am able to announce the availability of a position in the BSU, to work with me (it&#8217;s my old job!)</p>
<p>Official details are below, or you can find the full ad on the <a title="Job Advert" href="http://www15.i-grasp.com/fe/tpl_newcastle02.asp?s=zDmOlRWtGeVHmJjVeb&amp;jobid=41653,4722349883&amp;key=27835358&amp;c=478665875699&amp;pagestamp=dbxbhpfwxemtrgkrba">Newcastle University website</a>.</p>
<p><strong>Experimental Scientific Officer, Bioinformatics Support Unit</strong></p>
<p>£27,428 to £35,788 per annum</p>
<p>Closing Date: 11 September 2011</p>
<p>The Bioinformatics Support Unit at Newcastle University is a successful cross-Faculty service providing high quality scientific support for a range of bioinformatics projects.</p>
<p>We require an Experimental Scientific Officer, with experience of a range of Bioinformatics techniques, to work in the Unit on the development and delivery of scientific projects and liaison with relevant academics.</p>
<p>You should have at least a first degree in a relevant science related subject and preferably a PhD. You will have previous experience in bioinformatics support and an understanding of UK research funding procedures.</p>
<p>For an informal discussion on this opportunity, please contact <a title="Simon Cockell - staff profile" href="http://www.ncl.ac.uk/biomedicine/contact/profile/simon.cockell">Dr Simon Cockell</a> (Senior Experimental Scientific Officer).</p>
<p>The <a href="http://bsu.ncl.ac.uk/">BSU website</a> is a useful source of information on the kind of work we undertake. There&#8217;s a lot of analysis of high throughput data (as you would expect), but also opportunities to get involved with projects that have a bioinformatics research base. We support groups across the university, and beyond &#8211; in other north east universities and the local hospitals.</p>
<!-- kcite active, but no citations found -->
</div> <!-- kcite-section 14925 -->]]></content:encoded>
			<wfw:commentRss>http://blog.fuzzierlogic.com/archives/14925/feed</wfw:commentRss>
		<slash:comments>0</slash:comments>
	
	</item>
		<item>
		<title>Brand new same old job</title>
		<link>http://blog.fuzzierlogic.com/archives/12593</link>
		<comments>http://blog.fuzzierlogic.com/archives/12593#comments</comments>
		<pubDate>Tue, 19 Jul 2011 20:57:55 +0000</pubDate>
		<dc:creator>Simon</dc:creator>
				<category><![CDATA[Uncategorized]]></category>

		<guid isPermaLink="false">http://blog.fuzzierlogic.com/?p=12593</guid>
		<description><![CDATA[<p>The week before last I had my first job interview in 6 years (actually 6 years and one day, to be precise), and I&#8217;m delighted that 15 minutes after I left the interview room, I was offered the job.</p> <p>I wasn&#8217;t expecting to get a new job this year, I&#8217;m perfectly happy where I am. [...]]]></description>
			<content:encoded><![CDATA[<div class="kcite-section" kcite-section-id="12593">
<!-- coins metadata inserted by kblog-metadata -->
<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&amp;rfr_id=kblog-metadata.php&amp;rft.title=Brand+new+same+old+job&amp;rft.source=Fuzzier+Logic&amp;rft.date=2011-07-19&amp;rft.identifier=http%3A%2F%2Fblog.fuzzierlogic.com%2Farchives%2F12593&amp;rft.aulast=Cockell&amp;rft.aufirst=Simon&amp;rft.format=text&amp;rft.language=English"></span><p>The week before last I had my first job interview in 6 years (actually 6 years and one day, to be precise), and I&#8217;m delighted that 15 minutes after I left the interview room, I was offered the job.</p>
<p>I wasn&#8217;t expecting to get a new job this year, I&#8217;m perfectly happy where I am. I love my job. I enjoy the challenge of continually changing focus to work on different people&#8217;s projects, and of driving multiple lines of research all at once. However, this was an opportunity I simply couldn&#8217;t ignore. Because it is the same job, only better. Heck, I don&#8217;t even have to move desks (if I don&#8217;t want to).</p>
<p>See, this all came about because my esteemed colleague, and the founding head of the Newcastle Bioinformatics Support Unit, <a href="http://eridanus.net/">Daniel Swan</a>, has decided to move to pastures new, at <a title="Oxford Gene Technology" href="http://www.ogt.co.uk/" target="_blank">Oxford Gene Technology</a>. This means there was an opening to do pretty much what I already do, but while running the show too.</p>
<p>I&#8217;m very excited to have this opportunity. Dan will be sorely missed &#8211; I have very big boots to fill &#8211; but I&#8217;ll be working very hard to make sure the unit goes from strength to strength. Also, since I have effectively vacated my old job, we will be recruiting very shortly to fill that gap too. So watch this space if you&#8217;re interested in working in Bioinformatics support in the North East.</p>
<!-- kcite active, but no citations found -->
</div> <!-- kcite-section 12593 -->]]></content:encoded>
			<wfw:commentRss>http://blog.fuzzierlogic.com/archives/12593/feed</wfw:commentRss>
		<slash:comments>3</slash:comments>
	
	</item>
		<item>
		<title>Really impressed with Tagxedo &#8211; shaped word clouds. Here is a word cloud of my PhD thesis in the shape of a Drosophila:</title>
		<link>http://blog.fuzzierlogic.com/archives/7394</link>
		<comments>http://blog.fuzzierlogic.com/archives/7394#comments</comments>
		<pubDate>Thu, 02 Jun 2011 08:08:53 +0000</pubDate>
		<dc:creator>Simon</dc:creator>
				<category><![CDATA[Visualisation]]></category>
		<category><![CDATA[word-cloud]]></category>

		<guid isPermaLink="false">http://blog.fuzzierlogic.com/archives/7394</guid>
		<description><![CDATA[<a href="http://posterous.com/getfile/files.posterous.com/temp-2011-06-02/AwEdJxfbsekmkpltgbctsuaBbmoncAnnlkktrxnaxGgxCthyEtvsltgueiIk/thesis_dros.png.scaled1000.png"></a> <p>I worked on developmental genetics of Drosophila melanogaster for my PhD. You can find Tagxedo at <a title="Tagxedo" href="http://www.tagxedo.com/" target="_blank">http://www.tagxedo.com/</a>. A lot of the tools (such as adding your own images for word cloud shapes) are free in the beta, but I guess won&#8217;t be forever.</p> <p style="font-size: 10px;"><a href="http://posterous.com">Posted via email</a> from [...]]]></description>
			<content:encoded><![CDATA[<div class="kcite-section" kcite-section-id="7394">
<!-- coins metadata inserted by kblog-metadata -->
<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&amp;rfr_id=kblog-metadata.php&amp;rft.title=Really+impressed+with+Tagxedo+%26%238211%3B+shaped+word+clouds.+Here+is+a+word+cloud+of+my+PhD+thesis+in+the+shape+of+a+Drosophila%3A&amp;rft.source=Fuzzier+Logic&amp;rft.date=2011-06-02&amp;rft.identifier=http%3A%2F%2Fblog.fuzzierlogic.com%2Farchives%2F7394&amp;rft.aulast=Cockell&amp;rft.aufirst=Simon&amp;rft.format=text&amp;rft.language=English"></span><div class="posterous_autopost">
<div class="p_embed p_image_embed"><a href="http://posterous.com/getfile/files.posterous.com/temp-2011-06-02/AwEdJxfbsekmkpltgbctsuaBbmoncAnnlkktrxnaxGgxCthyEtvsltgueiIk/thesis_dros.png.scaled1000.png"><img src="http://posterous.com/getfile/files.posterous.com/temp-2011-06-02/AwEdJxfbsekmkpltgbctsuaBbmoncAnnlkktrxnaxGgxCthyEtvsltgueiIk/thesis_dros.png.scaled500.png" alt="Thesis_dros" width="500" height="232" /></a></div>
<p>I worked on developmental genetics of <em>Drosophila melanogaster</em> for my PhD. You can find Tagxedo at <a title="Tagxedo" href="http://www.tagxedo.com/" target="_blank">http://www.tagxedo.com/</a>. A lot of the tools (such as adding your own images for word cloud shapes) are free in the beta, but I guess won&#8217;t be forever.</p>
<p style="font-size: 10px;"><a href="http://posterous.com">Posted via email</a> from <a href="http://sjcockell.posterous.com/really-impressed-with-tagxedo-shaped-word-clo">Simon&#8217;s posterous</a></p>
<p>&nbsp;</p>
</div>
<!-- kcite active, but no citations found -->
</div> <!-- kcite-section 7394 -->]]></content:encoded>
			<wfw:commentRss>http://blog.fuzzierlogic.com/archives/7394/feed</wfw:commentRss>
		<slash:comments>0</slash:comments>
	
		<media:thumbnail url="http://posterous.com/getfile/files.posterous.com/temp-2011-06-02/AwEdJxfbsekmkpltgbctsuaBbmoncAnnlkktrxnaxGgxCthyEtvsltgueiIk/thesis_dros.png.scaled500.png" />
		<media:content url="http://posterous.com/getfile/files.posterous.com/temp-2011-06-02/AwEdJxfbsekmkpltgbctsuaBbmoncAnnlkktrxnaxGgxCthyEtvsltgueiIk/thesis_dros.png.scaled500.png" medium="image">
			<media:title type="html">Thesis_dros</media:title>
		</media:content>
	</item>
		<item>
		<title>Announcing a Bioinformatics Kblog writeathon</title>
		<link>http://blog.fuzzierlogic.com/archives/4451</link>
		<comments>http://blog.fuzzierlogic.com/archives/4451#comments</comments>
		<pubDate>Mon, 09 May 2011 13:59:33 +0000</pubDate>
		<dc:creator>Simon</dc:creator>
				<category><![CDATA[Knowledgeblog]]></category>
		<category><![CDATA[bioinformatics]]></category>
		<category><![CDATA[kblog]]></category>
		<category><![CDATA[knowledgeblog]]></category>
		<category><![CDATA[tutorials]]></category>

		<guid isPermaLink="false">http://blog.fuzzierlogic.com/?p=4451</guid>
		<description><![CDATA[<p>(Reposted from <a href="http://knowledgeblog.org/131">Knowledgeblog.org</a>)</p> <p>The Knowledgeblog team is holding a ‘writeathon’ to produce content for a tutorial-focused bioinformatics kblog.</p> <p>The event will be taking place in Newcastle on the 21st June 2011.  We’re looking for volunteer contributors who would like to join us in Newcastle on the day, or would like to contribute tutorial material remotely [...]]]></description>
			<content:encoded><![CDATA[<div class="kcite-section" kcite-section-id="4451">
<!-- coins metadata inserted by kblog-metadata -->
<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&amp;rfr_id=kblog-metadata.php&amp;rft.title=Announcing+a+Bioinformatics+Kblog+writeathon&amp;rft.source=Fuzzier+Logic&amp;rft.date=2011-05-09&amp;rft.identifier=http%3A%2F%2Fblog.fuzzierlogic.com%2Farchives%2F4451&amp;rft.aulast=Cockell&amp;rft.aufirst=Simon&amp;rft.format=text&amp;rft.language=English"></span><p><span style="font-size: 14px; line-height: 22px;">(Reposted from <a href="http://knowledgeblog.org/131">Knowledgeblog.org</a>)</span></p>
<div>
<p>The Knowledgeblog team is holding a ‘writeathon’ to produce content for a tutorial-focused bioinformatics kblog.</p>
<p>The event will be taking place in Newcastle on the 21st June 2011.  We’re looking for volunteer contributors who would like to join us in Newcastle on the day, or would like to contribute tutorial material remotely to the project.</p>
<p>We will be sending invites shortly to a few invited contributors but are looking for a total of 15 to 20 participants in total.</p>
<p>Travel and accommodation costs (where appropriate) can be reimbursed.</p>
<p>If you would like to contribute tutorial material on microarray analysis, proteomics, next-generation sequencing, bioinformatics workflow development, bioinformatics database resources, network analysis or data integration and receive a citable DOI for your work please get in touch with us at <a rel="noreferrer" href="https://mail.google.com/mail/?extsrc=mailto&amp;url=mailto%3Aadmin@knowledgeblog.org" target="_blank">admin@knowledgeblog.org</a></p>
<p>For more information about Knowledgeblog please see <a href="http://knowledgeblog.org/">http://knowledgeblog.org</a>.  For examples of existing Knowledgeblogs please see <a href="http://ontogeneis.knowledgeblog.org/">http://ontogeneis.knowledgeblog.org</a> and <a href="http://taverna.knowledgeblog.org/">http://taverna.knowledgeblog.org</a>.</p>
</div>
<!-- kcite active, but no citations found -->
</div> <!-- kcite-section 4451 -->]]></content:encoded>
			<wfw:commentRss>http://blog.fuzzierlogic.com/archives/4451/feed</wfw:commentRss>
		<slash:comments>1</slash:comments>
	
	</item>
		<item>
		<title>Automatic citation processing with Zotero and KCite</title>
		<link>http://blog.fuzzierlogic.com/archives/529</link>
		<comments>http://blog.fuzzierlogic.com/archives/529#comments</comments>
		<pubDate>Wed, 13 Apr 2011 09:43:17 +0000</pubDate>
		<dc:creator>Simon</dc:creator>
				<category><![CDATA[Knowledgeblog]]></category>
		<category><![CDATA[citations]]></category>
		<category><![CDATA[kblog]]></category>
		<category><![CDATA[referencing]]></category>
		<category><![CDATA[zotero]]></category>

		<guid isPermaLink="false">http://blog.fuzzierlogic.com/?p=529</guid>
		<description><![CDATA[<p>Writing papers. It&#8217;s a pain, right? Journals are finicky about formatting. You write the content and then the journal wants you to make it look right. You finally get the content in the right shape and then they tell you that you&#8217;ve formatted the bibliography wrong. Your bibliography is clearly in Harvard format, when the [...]]]></description>
			<content:encoded><![CDATA[<div class="kcite-section" kcite-section-id="529">
<!-- coins metadata inserted by kblog-metadata -->
<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&amp;rfr_id=kblog-metadata.php&amp;rft.title=Automatic+citation+processing+with+Zotero+and+KCite&amp;rft.source=Fuzzier+Logic&amp;rft.date=2011-04-13&amp;rft.identifier=http%3A%2F%2Fblog.fuzzierlogic.com%2Farchives%2F529&amp;rft.aulast=Cockell&amp;rft.aufirst=Simon&amp;rft.format=text&amp;rft.language=English"></span><p>Writing papers. It&#8217;s a pain, right? Journals are finicky about formatting. You write the content and then the journal wants <em>you </em>to make it look right. You finally get the content in the right shape and then they tell you that <em>you&#8217;ve</em> formatted the bibliography wrong. Your bibliography is clearly in Harvard format, when the journal only accepts papers where the bibliography is formatted Chicago style. Another hour or two of spitting and cursing as you try to massage the citations and bibliography into the &#8220;correct&#8221; format. You&#8217;re not even allowed to cite everything you want to, because <a href="http://blog.fejes.ca/?p=368">the internet is clearly so untrusted a resource</a>.
</p>
<p align='center'><img src="http://blog.fuzzierlogic.com/wp-content/uploads/2011/04/041311_0943_Automaticci1.jpg" alt=""/>
	</p>
<p>I&#8217;m of the opinion that publishing should be lightweight, the publishers should get out of the way of the author&#8217;s process, not actively get in the way. Working on the <a href="http://knowledgeblog.org/">Knowledgeblog</a> project has only reinforced this opinion. Why should I spend days formatting the content, when any web content management system (CMS) worth its salt will take raw content and format it in a consistent way? Why should I process all the citations and format the bibliography when it should be (relatively) simple to do this in software? Why should I spend time producing complicated figures that compromise what I am able to show when data+code would give the reader far more power to visualise my results themselves?
</p>
<p><a href="http://knowledgeblog.googlecode.com/files/aute_cite_process.docx">This document</a> is written in Word 2007 on a Windows 7 virtual machine. On this virtual machine I have also installed <a href="http://www.zotero.org/support/standalone">Standalone Zotero</a>. The final piece of this particular jigsaw is a <a href="http://citationstyles.org/">Citation Style Language</a> (CSL) style document I wrote (you can <a href="http://code.google.com/p/knowledgeblog/source/browse/trunk/tooling/CSL/kcite.csl">download it</a> from the <a href="http://code.google.com/p/knowledgeblog/">Knowledgeblog Google Code site</a>) that formats a citation in such a way that <a href="http://knowledgeblog.org/kcite-plugin/">KCite</a>, Knowledgeblog&#8217;s citation engine, can understand it. Now, when I insert citations into my Word document via the Zotero Add-In, I can pick the &#8220;KCite&#8221; style from the list, and the citation is popped into my document. Now when I hit &#8220;Publish&#8221; in Word, the document is pushed to my blog, KCite sees the citation as added by Zotero, and processes it, producing a nicely formatted bibliography. We are working on the <a href="http://gsl-nagoya-u.net/http/pub/citeproc-doc.html">citeproc-js</a> implementation that means the reader can format this bibliography any way they choose (<a href="http://www.russet.org.uk/blog/">Phil</a> has a working prototype of this). The biggest current limitation is that your Zotero library entry must have a DOI in it for everything to join up.
</p>
<p>So, here is a paragraph with some (contextually meaningless) citations in it <span class="kcite" kcite-id="ITEM-1">(<a href="http://dx.doi.org/10.1006/jmbi.1990.9999">http://dx.doi.org/10.1006/jmbi.1990.9999</a>)</span>
. All citations have been added into the Word doc via Zotero, and processed in the page you&#8217;re viewing by KCite <span class="kcite" kcite-id="ITEM-2">(<a href="http://dx.doi.org/10.1073/pnas.0400782101">http://dx.doi.org/10.1073/pnas.0400782101</a>)</span>
. Adding a reference into the document from your Zotero library takes 3-4 clicks, no further processing is needed <span class="kcite" kcite-id="ITEM-3">(<a href="http://dx.doi.org/10.1093/bioinformatics/btr134">http://dx.doi.org/10.1093/bioinformatics/btr134</a>)</span>
.
</p>
<p>Other popular reference management tools, such as <a href="http://www.mendeley.com/">Mendeley</a> and <a href="http://www.mekentosj.com/papers/">Papers</a>, also use CSL styles to format citations and bibliographies, so this same style could be employed to enable KCite referencing with those tools as well. This opens up a wide range of possible tool chains for effective blogging. Mendeley + <a href="http://www.openoffice.org/">OpenOffice</a> on Ubuntu. Papers + <a href="http://macromates.com/">TextMate</a> on OS X (Papers can be used to insert citations into more than just office suite documents, more on that in a later post). The possibilities are broad (but not endless, not yet anyway). Hopefully this means many people&#8217;s existing authoring toolchain is already fully supported by Knowledgeblog.
</p>
<p>Image credit: <a href="http://www.flickr.com/photos/sybrenstuvel/2468506922/">http://www.flickr.com/photos/sybrenstuvel/2468506922/</a> (<a href="http://www.flickr.com/photos/sybrenstuvel/">Sybren Stüvel</a> on Flickr)</p>


<p>Bibliography
      <div class="kcite-bibliography"></div>
</p>


<script type="text/javascript">
      var kcite_citation_data;
      if( kcite_citation_data == undefined ){
          kcite_citation_data = [];
      }
      kcite_citation_data[ 529 ] = {"ITEM-1":{"volume":"215","issue":"3","URL":"http://dx.doi.org/10.1006/jmbi.1990.9999","title":"Basic Local Alignment Search Tool","container-title":"Journal of Molecular Biology","publisher":"Elsevier BV","issued":{"date-parts":[[1990,10,5]]},"author":[{"family":"Altschul","given":"S"}],"editor":[],"page":"403-410","type":"article-journal","source":"doi","identifier":"10.1006/jmbi.1990.9999","resolved":true,"id":"ITEM-1"},"ITEM-2":{"volume":"101","issue":"16","URL":"http://dx.doi.org/10.1073/pnas.0400782101","title":"A gene atlas of the mouse and human protein-encoding transcriptomes","container-title":"Proceedings of the National Academy of Sciences","publisher":"Proceedings of the National Academy of Sciences","issued":{"date-parts":[[2004,4,6]]},"author":[{"family":"Su","given":"A. I."}],"editor":[],"page":"6062-6067","type":"article-journal","source":"doi","identifier":"10.1073/pnas.0400782101","resolved":true,"id":"ITEM-2"},"ITEM-3":{"volume":"27","issue":"9","URL":"http://dx.doi.org/10.1093/bioinformatics/btr134","title":"Customizable views on semantically integrated networks for systems biology","container-title":"Bioinformatics","publisher":"Oxford University Press (OUP)","issued":{"date-parts":[[2011,4,14]]},"author":[{"family":"Weile","given":"J."},{"family":"Pocock","given":"M."},{"family":"Cockell","given":"S. J."},{"family":"Lord","given":"P."},{"family":"Dewar","given":"J. M."},{"family":"Holstein","given":"E.-M."},{"family":"Wilkinson","given":"D."},{"family":"Lydall","given":"D."},{"family":"Hallinan","given":"J."},{"family":"Wipat","given":"A."}],"editor":[],"page":"1299-1306","type":"article-journal","source":"doi","identifier":"10.1093/bioinformatics/btr134","resolved":true,"id":"ITEM-3"}};
</script>


</div> <!-- kcite-section 529 -->]]></content:encoded>
			<wfw:commentRss>http://blog.fuzzierlogic.com/archives/529/feed</wfw:commentRss>
		<slash:comments>0</slash:comments>
	
		<media:thumbnail url="http://blog.fuzzierlogic.com/wp-content/uploads/2011/04/041311_0943_Automaticci1.jpg" />
		<media:content url="http://blog.fuzzierlogic.com/wp-content/uploads/2011/04/041311_0943_Automaticci1.jpg" medium="image" />
	</item>
		<item>
		<title>Stack Exchange and the future of BioStar</title>
		<link>http://blog.fuzzierlogic.com/archives/509</link>
		<comments>http://blog.fuzzierlogic.com/archives/509#comments</comments>
		<pubDate>Mon, 21 Mar 2011 22:00:03 +0000</pubDate>
		<dc:creator>Simon</dc:creator>
				<category><![CDATA[BioStar]]></category>
		<category><![CDATA[internet]]></category>
		<category><![CDATA[biostar]]></category>
		<category><![CDATA[stack-exchange]]></category>

		<guid isPermaLink="false">http://blog.fuzzierlogic.com/?p=509</guid>
		<description><![CDATA[<p>Over the weekend I saw <a title="='@spolsky" href="http://twitter.com/spolsky/status/49233944582946816" target="_blank">this tweet</a> from <a title="Stack Overflow" href="http://stackoverflow.com/" target="_blank">Stack Overflow</a>/<a title="Stack Exchange" href="http://stackexchange.com/" target="_blank">Exchange</a> founder <a title="Joel on Software" href="http://www.joelonsoftware.com/" target="_blank">Joel Spolsky</a>. The content of the link he posted has served to crystallise some of my thinking of the last couple of weeks with relation to the Bioinformatics [...]]]></description>
			<content:encoded><![CDATA[<div class="kcite-section" kcite-section-id="509">
<!-- coins metadata inserted by kblog-metadata -->
<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&amp;rfr_id=kblog-metadata.php&amp;rft.title=Stack+Exchange+and+the+future+of+BioStar&amp;rft.source=Fuzzier+Logic&amp;rft.date=2011-03-21&amp;rft.identifier=http%3A%2F%2Fblog.fuzzierlogic.com%2Farchives%2F509&amp;rft.aulast=Cockell&amp;rft.aufirst=Simon&amp;rft.format=text&amp;rft.language=English"></span><p>Over the weekend I saw <a title="='@spolsky" href="http://twitter.com/spolsky/status/49233944582946816" target="_blank">this tweet</a> from <a title="Stack Overflow" href="http://stackoverflow.com/" target="_blank">Stack Overflow</a>/<a title="Stack Exchange" href="http://stackexchange.com/" target="_blank">Exchange</a> founder <a title="Joel on Software" href="http://www.joelonsoftware.com/" target="_blank">Joel Spolsky</a>. The content of the link he posted has served to crystallise some of my thinking of the last couple of weeks with relation to the Bioinformatics question and answer site <a title="BioStar" href="http://biostar.stackexchange.com/" target="_blank">BioStar</a>.</p>
<p>The link Spolsky posted in the tweet was to a <a title="Atheism Stack Exchange proposal" href="http://area51.stackexchange.com/proposals/2732" target="_blank">failed Stack Exchange proposal</a>, and I found the page interesting not for the proposal, or the fact that it failed, but the clearly enumerated reasons for <em>why</em> it failed. Here&#8217;s a screenshot:</p>
<p style="text-align: center;"><a href='http://blog.fuzzierlogic.com/wp-content/uploads/2011/03/atheism_shutdown.png'><img class="aligncenter size-medium wp-image-511" title="Failed Stack Exchange proposal" src="http://blog.fuzzierlogic.com/wp-content/uploads/2011/03/atheism_shutdown.png" alt="Atheism SE Proposal Screen Cap" width="300" height="250" /></a></p>
<p>To clarify the procedure here, new Stack Exchange sites are proposed by a community of users. That community was originally drawn from Stack Overflow, the extremely successful programming Q&amp;A site, but now that there are nearly 50 active sites, the available community of proposers is much larger. Newly proposed sites have to overcome a series of hurdles before they go live, from proposal, through commitment, to a private beta, a public beta, before finally becoming a fully-fledged SE site. At the end of each of these stages, sites are assessed for the likelihood that they will become a healthy and active site. Crucially, this assessment appears to not be an individual process. It is obviously the view of the SE powers-that-be that all Q&amp;A sites are created equal, and what works for one will work for all of them. What is worrying about this attitude is that sites that are genuinely niche and likely to have a small, but active and dedicated, community will be left by the wayside, since presumably they will be unable to generate the kind of ad-revenue that Spolsky <em>at al</em> are going to require to repay their investors.</p>
<p>BioStar is a web community reaching a crossroads. The site is running on the now-free, but inevitably unsupported Stack Exchange 1.0 platform (the process discussed above is for the SE 2.0 community). To continue to thrive, I firmly believe the site needs to move on from this platform, since it is almost certainly going to be closed down from under it within the next 12-18 months. This presents the site owners (and us, the community) with a choice.</p>
<ol>
<li>Migrate the site to SE 2.0</li>
<li>Change to an open-source alternative Q&amp;A platform</li>
<li>Roll-our-own site, with the functionality we require</li>
</ol>
<p>I will start by ruling out option 3. Bioinformatics teaches us the perils of reinventing the wheel when it is not necessary. An effort to write a custom-built platform for BioStar would be almost entirely redundant, undertaken on the free time of the community (free-time which could be better spent answering questions on BioStar), and almost certainly offer no tangible benefit over using one of the already available Q&amp;A engines. (Think Facebook-for-Scientists&#8230;)</p>
<p>I used to be firmly in the camp supporting option 1. I genuinely love Stack Overflow. I have found great utility in some of the Stack Exchange family of sites. However, the attitude betrayed in both Spolsky&#8217;s tweet and the closure notice on the Atheism Stack Exchange site makes me think that BioStar would be left out in the cold if we attempted this migration. Let&#8217;s look at how BioStar measures up to these numbers:</p>
<ul>
<li>Questions per day (SE 2.0 recommends &#8211; &#8220;15 questions per day on average is a healthy beta&#8221;)
<ul>
<li>Since 30th September 2009 BioStar has received 1,681 questions &#8211; that&#8217;s 3.13 questions per day</li>
</ul>
</li>
<li>Percentage answered (SE 2.0 &#8211; &#8220;90% answered is a healthy beta&#8221;)
<ul>
<li>BioStar does well here. There are currently 47 questions with no upvoted answers &#8211; about 2.8%</li>
</ul>
</li>
<li>User group (SE 2.0 &#8211; 150 users with 200+, 10 with 2,000+, 5 with 3,000+)
<ul>
<li>We have 14 users with 3,000+, 24 with 2,000+ and (by my count) 142 with 200+. But BioStar has been going for 18 months, the atheism SE site was shut down after 2 months in public beta</li>
</ul>
</li>
<li>Answer ratio (SE 2.0 &#8211; &#8220;2.5 answers per question is good&#8221;)
<ul>
<li>I don&#8217;t have easy access to precise numbers for this, but it&#8217;s around 3 answers per question on BioStar</li>
</ul>
</li>
<li>Visits per day (SE 2.0 &#8211; &#8220;1,500 visits per day is good, 500 visits per day is worrying.&#8221;)
<ul>
<li>I have no stats at all for this, but I&#8217;m willing to put good money on the fact that daily numbers are much closer to 500 than 1,500.</li>
</ul>
</li>
</ul>
<p>By these criteria, and judging by the Atheism Stack Exchange linked to by Spolsky, BioStar would fail to emerge from SE 2.0 beta, based on current numbers, and any effort the existing community put in to get it that far would be wasted. And I don&#8217;t think the audience of the site would be grown dramatically by it being a Stack Exchange 2.0 site. I think we have to accept that Bioinformatics is a niche subject with a relatively small potential audience, one that is not going to be especially interesting to a commercially driven exercise (such as Stack Exchange necessarily has to be).</p>
<p>So that leaves us with migration to an OSS alternative as the only remaining option. There are a number of platforms available, some of which offer an experience extremely close to &#8216;real&#8217; Stack Exchange. I would pick one of these that allows an existing SE XML dump to be imported, and migrate the site as soon as possible, certainly within the next 6 months. There is no question that the change over will be painful, and will probably cost the site a few users, and some traffic in the first instance (the biostar.stackexchange.com URL will have to go, for example), but I am confident in the community that has been built around the site &#8211; it will survive, and will be all the stronger for the change.</p>
<p>Besides, if we look at the facts in the cold, hard light of day, we really have no choice.</p>
<!-- kcite active, but no citations found -->
</div> <!-- kcite-section 509 -->]]></content:encoded>
			<wfw:commentRss>http://blog.fuzzierlogic.com/archives/509/feed</wfw:commentRss>
		<slash:comments>8</slash:comments>
	
		<media:thumbnail url="http://blog.fuzzierlogic.com/wp-content/uploads/2011/03/Screen-shot-2011-03-21-at-20.46.47-150x150.png" />
		<media:content url="http://blog.fuzzierlogic.com/wp-content/uploads/2011/03/Screen-shot-2011-03-21-at-20.46.47.png" medium="image">
			<media:title type="html">Failed Stack Exchange proposal</media:title>
			<media:thumbnail url="http://blog.fuzzierlogic.com/wp-content/uploads/2011/03/Screen-shot-2011-03-21-at-20.46.47-150x150.png" />
		</media:content>
	</item>
	</channel>
</rss>

